| Secretary of State | John Forsyth (Cont.) |
| Secretary of the Treasury | Levi Woodbury (Cont.) |
| Secretary of War | Joel R. Poinsett, 1837 |
| Attorney General | Benjamin F. Butler (Cont.) Felix Grundy, 1838 Henry D. Gilpin, 1840 |
| Postmaster General | Amos Kendall (Cont.) John M. Niles, 1840 |
| Secretary of the Navy | Mahlon Dickerson (Cont.) James K. Paulding, 1838 |