| Secretary of State | Daniel Webster (Cont.) Abel P. Upshur, 1843 John C. Calhoun, 1844 |
| Secretary of the Treasury | Thomas Ewing (Cont.) Walter Forward, 1841 George M. Bibb, 1844 |
| Secretary of War | John Bell (Cont.) John C. Spencer, 1841 William Wilkins, 1844 |
| Attorney General | John J. Crittenden (Cont.) Hugh S. Legaré, 1841 John Nelson, 1843 |
| Postmaster General | Francis Granger (Cont.) Charles A. Wickliffe, 1841 |
| Secretary of the Navy | George E. Badger (Cont.) Abel P. Upshur, 1841 Thomas W. Gilmer, 1844 John Y. Mason, 1844 |