| Secretary of State | John M. Clayton, 1849 |
| Secretary of the Treasury | William M. Meredith, 1849 |
| Secretary of War | George W. Crawford, 1849 |
| Attorney General | Reverdy Johnson, 1849 |
| Postmaster General | Jacob Collamer, 1849 |
| Secretary of the Navy | William B. Preston, 1849 |
| Secretary of the Interior | Thomas Ewing, 1849 |