| Secretary of State | Philander C. Knox, 1909 |
| Secretary of the Treasury | Franklin MacVeagh, 1909 |
| Secretary of War | Jacob M. Dickinson, 1909 Henry L. Stimson, 1911 |
| Attorney General | George W. Wickersham, 1909 |
| Postmaster General | Frank H. Hitchcock, 1909 |
| Secretary of the Navy | George von L. Meyer, 1909 |
| Secretary of the Interior | Richard A. Ballinger, 1909 Walter L. Fisher, 1911 |
| Secretary of Agriculture | James Wilson (Cont.) |
| Secretary of Commerce and Labor | Charles Nagel, 1909 |