| Secretary of State | James Buchanan, 1845 |
| Secretary of the Treasury | Robert J. Walker, 1845 |
| Secretary of War | William L. Marcy, 1845 |
| Attorney General | John Y. Mason, 1845 Nathan Clifford, 1846 Isaac Toucey, 1848 |
| Postmaster General | Cave Johnson, 1845 |
| Secretary of the Navy | George Bancroft, 1845 John Y. Mason, 1846 |