| Secretary of State | William L. Marcy, 1853 |
| Secretary of the Treasury | James Guthrie, 1853 |
| Secretary of War | Jefferson Davis, 1853 |
| Attorney General | Caleb Cushing, 1853 |
| Postmaster General | James Campbell, 1853 |
| Secretary of the Navy | James C. Dobbin, 1853 |
| Secretary of the Interior | Robert McClelland, 1853 |