| Secretary of State | John Sherman, 1897 William R. Day, 1898 John Hay, 1898 |
| Secretary of the Treasury | Lyman J. Gage, 1897 |
| Secretary of War | Russell A. Alger, 1897 Elihu Root, 1899 |
| Attorney General | Joseph McKenna, 1897 John W. Griggs, 1898 Philander C. Knox, 1901 |
| Postmaster General | James A. Gary, 1897 Charles E. Smith, 1898 |
| Secretary of the Navy | John D. Long, 1897 |
| Secretary of the Interior | Cornelius N. Bliss, 1897 Ethan A. Hitchcock, 1898 |
| Secretary of Agriculture | James Wilson, 1897 |