| Secretary of State | Dean Rusk (Cont.) |
| Secretary of the Treasury | C. Douglas Dillon (Cont.) Henry H. Fowler, 1965 |
| Secretary of Defense | Robert S. McNamara (Cont.) Clark M. Clifford, 1968 |
| Attorney General | Robert F. Kennedy (Cont.) N. de B. Katzenbach, 1965 Ramsey Clark, 1967 |
| Postmaster General | John A. Gronouski (Cont.) Lawrence F. O'Brien, 1965 W. Marvin Watson, 1968 |
| Secretary of the Interior | Stewart L. Udall (Cont.) |
| Secretary of Agriculture | Orville L. Freeman (Cont.) |
| Secretary of Commerce | Luther H. Hodges (Cont.) John T. Connor, 1964 A. B. Trowbridge, 1967 C. R. Smith, 1968 |
| Secretary of Labor | W. Willard Wirtz (Cont.) |
| Secretary of Health, Education, and Welfare | Anthony J. Celebrezze (Cont.) John W. Gardner, 1965 Wilbur J. Cohen, 1968 |
| Secretary of Housing and Urban Development | Robert C. Weaver, 1966 |
| Secretary of Transportation | Alan S. Boyd, 1966 |