| Secretary of State | Charles E. Hughes, 1921 |
| Secretary of the Treasury | Andrew W. Mellon, 1921 |
| Secretary of War | John W. Weeks, 1921 |
| Attorney General | Harry M. Daugherty, 1921 |
| Postmaster General | Will H. Hays, 1921 Hubert Work, 1922 Harry S. New, 1923 |
| Secretary of the Navy | Edwin Denby, 1921 |
| Secretary of the Interior | Albert B. Fall, 1921 Hubert Work, 1923 |
| Secretary of Agriculture | Henry C. Wallace, 1921 |
| Secretary of Commerce | Herbert Hoover, 1921 |
| Secretary of Labor | James J. Davis, 1921 |