| Secretary of State | Daniel Webster, 1850 Edward Everett, 1852 |
| Secretary of the Treasury | Thomas Corwin, 1850 |
| Secretary of War | Charles M. Conrad, 1850 |
| Attorney General | John J. Crittenden, 1850 |
| Postmaster General | Nathan K. Hall, 1850 Samuel D. Hubbard, 1852 |
| Secretary of the Navy | William A. Graham, 1850 John P. Kennedy, 1852 |
| Secretary of the Interior | Thos. M. T. McKennan, 1850 Alex. H. H. Stuart, 1850 |